BIOMO301-22B (HAM)

Advanced Biochemistry

15 Points

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Division of Health Engineering Computing & Science
School of Science
Biomedical, Molecular and Cellular Biology

Staff

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: cheryl.ward@waikato.ac.nz

You can contact staff by:

  • Calling +64 7 838 4466 select option 1, then enter the extension.
  • Extensions starting with 4, 5, 9 or 3 can also be direct dialled:
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    • For extensions starting with 3: dial +64 7 2620 + the last 3 digits of the extension e.g. 3123 = +64 7 262 0123.
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Paper Description

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In this paper, students will engage with cutting-edge biochemical research and its applications. We will build on the principles of biochemistry introduced in BIOMO201 to investigate new and emerging research and biochemical techniques. An example of topics to be covered includes Molecular Assemblies, Protein Trafficking and Secretion, Molecular Motors, Nucleotide Biosynthesis and DNA replication and repair. We apply these topics to real-life situations for example; biotechnology applications of DNA replication and repair enzymes, protein engineering, and cancer treatments.

This interactive course will be run over a series of lectures and workshops and underpinned by practical sessions in the laboratory where students produce and characterise an enzyme that is millions of years old and its modern-day counterpart. Students will write up the results from their practical sessions as a 'mini-research report' (lab report) giving them critical evaluation and writing skills that can be applied to graduate study or the workplace.

Students who complete this course will have a thorough understanding of new and emerging biochemical research, techniques, and their applications, as well as learning key laboratory and research skills.

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Paper Structure

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This paper will be taught via lectures, workshops and practical sessions. The paper assesment is 100% internally assessed (no final examAssessments are in the form of workshop assessments (20%), three tests (15% each), laboratory sessions (15%), and a lab report (20%).

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Learning Outcomes

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Students who successfully complete the paper should be able to:

  • Evaluate biochemical techniques and their applications
    Linked to the following assessments:
  • Describe key cellular processes including DNA replication, metabolism and protein trafficking
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  • Analyse molecular assemblies and their various functions
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  • Illustrate how DNA repair enzymes work and their use in biotechnology applications
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  • Evaluate how molecular motors transform chemical energy into mechanical work
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  • Investigate proteins using a variety of laboratory techniques
    Linked to the following assessments:
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Assessment

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Internal:external assessment ratio 100:0 (no final exam)

Assessment consists of the following:
Workshop assessment activities -9 in person workshops over the semester (20%)

Test 1 (15%)

Test 2 (15%)

Test 3 (15%)

Practical Sessions (Lab Book) (15%)

Lab report (mini-research report of the experiments performed over the practical sessions) (20%)

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Assessment Components

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The internal assessment/exam ratio (as stated in the University Calendar) is 100:0. There is no final exam. The final exam makes up 0% of the overall mark.

The internal assessment/exam ratio (as stated in the University Calendar) is 100:0 or 0:0, whichever is more favourable for the student. The final exam makes up either 0% or 0% of the overall mark.

Component DescriptionDue Date TimePercentage of overall markSubmission MethodCompulsory
1. Workshop Assessments
20
  • Hand-in: In Workshop
  • Online: Submit through Moodle
2. Test 1
12 Aug 2022
12:00 PM
15
  • Hand-in: In Lecture
3. Test 2
23 Sep 2022
12:00 PM
15
  • Hand-in: In Lecture
4. Test 3
21 Oct 2022
12:00 PM
15
  • Hand-in: In Lecture
5. Practical Sessions (Lab Book)
15
  • Hand-in: In Lab
6. Mini-research Report (Lab Report)
28 Oct 2022
5:00 PM
20
  • Online: Submit through Moodle
Assessment Total:     100    
Failing to complete a compulsory assessment component of a paper will result in an IC grade
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Required and Recommended Readings

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Required Readings

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Text book: Appling, Anthony-Cahill & Mathews, Biochemistry: Concepts & Connections, 2018 2nd edition, Pearson Education (or Garnett & Grisham, Biochemistry, 6th edition can be used in 2022).

Lab and Lecture powerpoints: A copy of the lab manual can be picked up from the Waikato Print (Gravitas) (prior to the start of the labs). All lecture powerpoints will be on Moodle.

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Online Support

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This paper has a Moodle page (http://elearn.waikato.ac.nz) where you will be able to access pdfs of lecture notes and powerpoints, lecture recordings, and assessment materials. There are also discussion forums where you can both ask and answer questions.

PLEASE NOTE: Moodle will be used for class notices etc and it is your responsibility to check the site regularly. Instructions provided on Moodle and in lectures are considered to be given to the class as a whole.

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Workload

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  • Lectures (24 hours contact)
  • Workshops (9 hours contact + 1-2 hours preparation per workshop)
  • Laboratory classes (18 hours contact)
  • Lab report (2 hours per week non-contact)
  • Three Tests (3 hours contact + revision hours)
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Linkages to Other Papers

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Prerequisite(s)

Prerequisite papers: BIOMO201 or BIOL251

Corequisite(s)

Equivalent(s)

Restriction(s)

Restricted papers: BIOL351 and ENMP425

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