BIOMO302-23A (HAM)

Advanced Genetics

15 Points

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Division of Health Engineering Computing & Science
School of Science
Biomedical, Molecular and Cellular Biology

Staff

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Convenor(s)

Linda Peters

Linda Peters
5110
E.3.08
See Moodle
linda.peters@waikato.ac.nz

Lecturer(s)

Brett Langley

Brett Langley
4060
C.2.04
See Moodle
brett.langley@waikato.ac.nz

Administrator(s)

Placement/WIL Coordinator(s)

Tutor(s)

Student Representative(s)

Lab Technician(s)

Librarian(s)

: cheryl.ward@waikato.ac.nz

You can contact staff by:

  • Calling +64 7 838 4466 select option 1, then enter the extension.
  • Extensions starting with 4, 5, 9 or 3 can also be direct dialled:
    • For extensions starting with 4: dial +64 7 838 extension.
    • For extensions starting with 5: dial +64 7 858 extension.
    • For extensions starting with 9: dial +64 7 837 extension.
    • For extensions starting with 3: dial +64 7 2620 + the last 3 digits of the extension e.g. 3123 = +64 7 262 0123.
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What this paper is about

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Tena koutou katoa. Welcome to Advanced Genetics.

This course will be taught be Dr Linda Peters, Associate Professor Brett Langley and a variety of guest lecturers from local industry.

We also have a new Advanced Technical Officer joining the laboratory team, Dr Geetanjali Rai.

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How this paper will be taught

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This paper follows on from BIOMO202-22B and deals in greater details with bacterial and mammalian genomes, molecular events within the cell, the expression and editing of genes, genetic variation, inheritance, human disease, complex traits, genetic analyses and population genetics. This paper is recommended to all biologists; it complements ecological, physiology and biochemical studies and aims to illustrate how genes interact in genomes, organisms, populations and human disease.

There will be two laboratory streams on offer (MON PM or TUES PM) with ten laboratory sessions (mostly every week). This will cater for timetable clashes with BIOMD303 and CHEMY301. You will need to print or use the electronic lab manual (to be available on Moodle) but also be provided with a 1B5 notebook that you will record all your methodologies used, data observations and analyses.

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Required Readings

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Genetics: From Genes to Genomes, Goldberg, Fischer, Hood & Hartwell, 7th Ed, 2021

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You will need to have

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1) Print a hard copy of the lab manual or bring/borrow an electronic device to review. It is important that you read the lab manual prior to entering class and attend/watch the appropriate supporting lectures and videos on Moodle.

2) Complete any Moodle quizzes that are required to completed prior to and after the lab. Details can be found on moodle under the "assessments" topic and on the lecture notes.

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Learning Outcomes

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Students who successfully complete the course should be able to:

  • Perform a range of practical laboratory techniques, including DNA and RNA extraction, gene editing, cDNA preparation, real-time PCR, gel electrophoresis, and experimental design and analysis
    Linked to the following assessments:
  • To describe the replication of viruses in their host cells
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  • To describe the various classes of genetic disease
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  • To describe what CRISPR is and how it can be used as an biotechnological or clinical application
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  • To discuss the genetic basis of cancer
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  • To discuss the major causes of human genetic diversity
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  • To distinguish between the three types of stem cells and their use in research and in the clinic
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  • To explain gene variation and frequency in populations
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  • To explain how DNA is packaged and its influence on gene expression
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  • To explain how microbial chromosomes are replicated
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  • To explain the potential influence of genetic discovery and technologies in medicine for diagnosis and treatment
    Linked to the following assessments:
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Assessments

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How you will be assessed

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The dates indicated for assessment procedures will normally be adhered to. Any changes to the dates will be made in consultation with the class at least one week prior to the original date. Attendance of the laboratory sessions are an essential element of the course and must be completed in order to pass the course. This will be evident by submitting your 1B5 lab notebook for grading with evidence of experimental analysis. Medical certificates must be presented for any test and/or laboratory missed.
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The internal assessment/exam ratio (as stated in the University Calendar) is 50:50. There is no final exam. The final exam makes up 50% of the overall mark.

The internal assessment/exam ratio (as stated in the University Calendar) is 50:50 or 0:0, whichever is more favourable for the student. The final exam makes up either 50% or 0% of the overall mark.

Component DescriptionDue Date TimePercentage of overall markSubmission MethodCompulsory
1. Moodle quizzes
5
  • Online: Submit through Moodle
2. Theory Test I
22 Mar 2023
10:00 AM
10
  • In Class: In Lecture
3. Theory Test II
3 May 2023
10:00 AM
10
  • Hand-in: In Lecture
4. 1B5 Laboratory Notebook (Labs 1-5)
6 Apr 2023
4:30 PM
12.5
  • Hand-in: Faculty Information (FG Link)
5. 1B5 Laboratory Notebook (Labs 6-10)
26 May 2023
4:30 PM
12.5
  • Hand-in: Faculty Information (FG Link)
6. Exam
50
✔
Assessment Total:     100    
Failing to complete a compulsory assessment component of a paper will result in an IC grade
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