BIOMO502-21A (HAM)

Molecular Genetics in Health and Disease

15 Points

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Division of Health Engineering Computing & Science
School of Science
Biomedical, Molecular and Cellular Biology

Staff

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Convenor(s)

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: cheryl.ward@waikato.ac.nz

You can contact staff by:

  • Calling +64 7 838 4466 select option 1, then enter the extension.
  • Extensions starting with 4, 5, 9 or 3 can also be direct dialled:
    • For extensions starting with 4: dial +64 7 838 extension.
    • For extensions starting with 5: dial +64 7 858 extension.
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    • For extensions starting with 3: dial +64 7 2620 + the last 3 digits of the extension e.g. 3123 = +64 7 262 0123.
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Paper Description

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This paper explores how recent advances in molecular biology are contributing to our understanding of molecular genetics and how this information is being exploited to benefit animal and human health. This paper will examine four key areas of molecular genetics; genomics, epigenomics, transcriptomics and proteomics with six exciting topics. Particular attention will be paid to key genetic changes that occurred during hominid evolution to adapt to the changing environment, how to edit genomes using CRISPR, how to identify polymorphic variations and disease susceptibility within genomes, how to monitor gene expression at the level of RNA and protein during disease, and understand the role of mutations in disease such as cancer. In addition, discuss the ethics of genetic testing, and medical treatment options.


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Paper Structure

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Three-hour sessions divided into ten seminars on six selected topics. The class has been provided 3 hours to ensure active discussion and fair participation. However, in some circumstance due to the nature of the topic and number of students, it maybe less than three hours.

Attendance to each of these sessions is necessary for the internal marks to be awarded. You will be expected to attend these seminars and read the reading list (section of scientific journal papers) prior to class.

There will be two topics that will be presented via ZOOM Topics II and IV. The rest will be taught face-to-face in E2.10 as a powerpoint presentation, two page summary, group discussion, or poster.


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Learning Outcomes

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Students who successfully complete the paper should be able to:

  • Communicate scientific ideas and concepts through essays and in-class presentations that uses standard scientific conventions to present an evidence-based argument on a particular position.
    Linked to the following assessments:
  • Describe how molecular genetics can benefit human and animal health.
    Linked to the following assessments:
  • Discuss the major advances that have been made within the areas of genomics, epigenomics, transcriptomics and proteomics.
    Linked to the following assessments:
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Assessment

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The assessment will involve a variety of platforms:

  • oral, written, and/or participation (by asking and or answering questions)
  • indépendant or group work
  • online or in person with face-to-face discussions
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Assessment Components

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The internal assessment/exam ratio (as stated in the University Calendar) is 50:50. There is no final exam. The final exam makes up 50% of the overall mark.

The internal assessment/exam ratio (as stated in the University Calendar) is 50:50 or 0:0, whichever is more favourable for the student. The final exam makes up either 50% or 0% of the overall mark.

Component DescriptionDue Date TimePercentage of overall markSubmission MethodCompulsory
1. Topic I - Human Adaption
11 Mar 2021
9:00 AM
5
  • Presentation: In Class
2. Topic II - Developmental Genetics
25 Mar 2021
9:00 AM
5
  • Presentation: In Class
3. Topic III - Dairy Research
15 Apr 2021
5:00 PM
5
  • Online: Submit through Moodle
4. Topic IV - Ageing
29 Apr 2021
9:00 AM
5
  • Online: Submit through Moodle
  • Presentation: In Class
5. Topic V - Cancer
13 May 2021
9:00 AM
15
  • Online: Submit through Moodle
  • Presentation: In Class
6. Topic VI - Gene Therapy
3 Jun 2021
9:00 AM
15
  • Presentation: In Class
7. Exam
50
Assessment Total:     100    
Failing to complete a compulsory assessment component of a paper will result in an IC grade
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Required and Recommended Readings

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Required Readings

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Each week readings from selected scientific journals will be provided on Moodle or during class. You may be assigned a whole journal article or simply a page or even a paragraph. Assigned roles will be via a random draw (during class), or from a list available on Moodle (on a first in first served basis when the date/time Moodle page is available online). Also, students in some circumstances can pick their own papers from their literature search.
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Other Resources

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Attending

  • School of Science Seminars
  • Seminars at LIC or AgResearch (relevant seminars will be advised via BIOMO502 Moodle page).
  • Waikato District Health Board Clinical School Seminars at Waikato Hospital (Usually held in March and Sept)
  • Library tutorials - Getting Started with EndNote, Searching Databases.

Online search engines:

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Online Support

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This paper has a Moodle page (http://elearn.waikato.ac.nz) where you will be able to access pdf’s of seminar notes and powerpoints, papers from selected journals and assessment materials. There are also discussion forums where you can both ask and answer questions.

PLEASE NOTE: Moodle will be used for class notices etc and it is your responsibility to check the site regularly. Instructions provided on Moodle and in seminars are considered to be given to the class as a whole.


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Workload

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10 hours per week (3 hr seminar and 7h independent study).


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Linkages to Other Papers

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This paper supports five other papers in the Molecular and Cellular major (physiology, biochemistry, microbiology, and two molecular application papers which are biomedical or environmentally focused) within the School of Science. In addition, the paper is complementary to COMPX555 (Bioinformatics) that is offered by HECS, CHEMY511 (Structural Characterisation) and SCIEN511 (Scientific Supercomputing).
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Prerequisite(s)

Prerequisites: BIOMO302 or BIOL310

Corequisite(s)

Equivalent(s)

Restriction(s)

Restricted papers: BIOL584 and BIOL585

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